ACTN3

Across TCGA patient cohorts, ACTN3 mutation is significantly associated with the total protein of many other genes, with 47 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ACTN3-associated genes across cancer lineages are 4E-BP1, EGFR_pY1068, and eIF4G. Each is linked with ACTN3 in more than 2 cancer types. Because this analysis shows association rather than direction, both ACTN3-to-partner and partner-to-ACTN3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 4E-BP1 grouped by ACTN3-low versus ACTN3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ACTN3→partner) and Y-score (partner→ACTN3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	4E-BP1 →	+0.334	+3.029	<.001	<.001	3	3
UCEC	EGFR_pY1068 →	-0.201	-1.502	.010	.027	3	2
UCEC	eIF4G →	+0.202	+1.874	.038	.049	3	2
UCEC	Acetyl-a-Tubulin-Lys40 →	+0.416	+1.584	.009	.005	3	2
UCEC	Notch1 →	+0.154	+1.836	<.001	.001	3	2
UCEC	Src_pY527 →	-0.323	-2.222	.017	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 47 associations by consensus.

4E-BP1 by ACTN3 expression — UCEC

Explore this box plot interactively →