ACTN2

Across TCGA patient cohorts, ACTN2 RNA expression is significantly associated with the protein abundance of many other proteins, with 17,107 significant associations in total. HNSC shows the largest number of these associations.

The most reproducible ACTN2-associated proteins across cancer lineages are PALM, CEP170, and CLINT1. Each is linked with ACTN2 in more than 5 cancer types. Because this analysis shows association rather than direction, both ACTN2-to-partner and partner-to-ACTN2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, ACTN2 versus PALM in HNSC, with a Pearson correlation of 0.37.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (ACTN2→partner) and Y-score (partner→ACTN2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	PALM →	+0.521	+2.364	<.001	<.001	3	6
OV	CEP170 →	+0.309	+0.223	.003	.001	3	5
COAD	CLINT1 →	-0.206	-0.082	.002	.006	2	6
COAD	DAPK1 →	+0.858	+0.105	.004	<.001	3	5
COAD	AKAP12_S612 →	+0.945	+0.095	<.001	.001	3	5
LSCC	FERMT2 →	+0.458	+0.435	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 17,107 associations by consensus.

ACTN2 vs PALM — HNSC

Explore this scatter interactively →