ACTN2

Across TCGA patient cohorts, ACTN2 protein abundance is significantly associated with the RNA expression of many other genes, with 9,715 significant associations in total. GBM shows the largest number of these associations.

The most reproducible ACTN2-associated genes across cancer lineages are TAL1, SORBS1, and CASQ2. Each is linked with ACTN2 in more than 5 cancer types. Because this analysis shows association rather than direction, both ACTN2-to-partner and partner-to-ACTN2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, ACTN2 versus TAL1 in GBM, with a Pearson correlation of 0.29.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ACTN2→partner) and Y-score (partner→ACTN2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	TAL1 →	+0.763	+0.563	<.001	<.001	3	5
COAD	SORBS1 →	+1.837	+0.517	.003	.002	2	6
HNSC	CASQ2 →	+2.383	+1.344	<.001	<.001	3	5
HNSC	CNRIP1 →	+0.564	+1.150	<.001	<.001	3	5
CCRCC	IL1RL1 →	+0.969	+0.549	.008	.003	3	4
COAD	ABI3BP →	+1.371	+0.443	<.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 9,715 associations by consensus.

ACTN2 vs TAL1 — GBM

Explore this scatter interactively →