ACTN2

Across TCGA patient cohorts, ACTN2 mutation is significantly associated with the total protein of many other genes, with 83 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ACTN2-associated genes across cancer lineages are Notch1, PCNA, and p38-MAPK_pT180_Y182. Each is linked with ACTN2 in more than 2 cancer types. Because this analysis shows association rather than direction, both ACTN2-to-partner and partner-to-ACTN2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by ACTN2-low versus ACTN2-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ACTN2→partner) and Y-score (partner→ACTN2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	Notch1 →	+0.205	+3.169	.004	.018	3	3
STAD	PCNA →	+0.379	+3.000	.002	.033	3	3
UCEC	p38-MAPK_pT180_Y182 →	-0.329	-1.571	.020	.005	3	3
UCEC	PDCD4 →	-0.448	-1.353	.002	.015	3	3
LUAD	Src_pY416 →	-0.303	-1.765	.003	.010	3	3
UCEC	STAT3_pY705 →	-0.398	-1.864	<.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 83 associations by consensus.

Notch1 by ACTN2 expression — STAD

Explore this box plot interactively →