ACTN2

Across TCGA cell cohorts, ACTN2 mutation is significantly associated with the RNA expression of many other genes, with 1,791 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ACTN2-associated genes across cancer lineages are CENPM, RAB5IF, and NISCH. Each is linked with ACTN2 in more than 1 cancer types. Because this analysis shows association rather than direction, both ACTN2-to-partner and partner-to-ACTN2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CENPM grouped by ACTN2-low versus ACTN2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ACTN2→partner) and Y-score (partner→ACTN2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CENPM →	+0.703	+1.721	<.001	.003	3	2
LARGE_INTESTINE	RAB5IF →	-0.548	-3.459	.001	.001	3	2
LARGE_INTESTINE	NISCH →	+0.632	+1.874	.001	.001	3	2
LARGE_INTESTINE	IL7 →	+0.823	+1.807	<.001	.003	3	2
LARGE_INTESTINE	GSR →	+0.713	+3.409	.001	<.001	3	2
LARGE_INTESTINE	UBXN8 →	+0.849	+3.459	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,791 associations by consensus.

CENPM by ACTN2 expression — LARGE_INTESTINE

Explore this box plot interactively →