ACTN1

Across TCGA pan-cancer cohorts, ACTN1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated ACTN1 data layer compared with 26 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher ACTN1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated ACTN1 expression acts as an unfavorable survival marker.

LSCC, CCRCC, and GBM are the cancer types where ACTN1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Tertile	II,III,IV	0.530	0.939	.010	22	view →
CCRCC	OS	Tertile	IV	0.198	0.830	.024	16	view →
GBM	OS	Median	All	0.260	0.523	.003	13	view →
PDAC	DFS	Median	IV	0.214	0.785	.006	12	view →
LUAD	OS	Quartile	II,III,IV	0.318	0.866	.017	6	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

ACTN1–LSCC (DFS)

Open the LSCC breakdown →