ACTN1

Across TCGA patient cohorts, ACTN1 protein abundance is significantly associated with the RNA expression of many other genes, with 18,381 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible ACTN1-associated genes across cancer lineages are FN1, CALD1, and CNN1. Each is linked with ACTN1 in more than 9 cancer types. Because this analysis shows association rather than direction, both ACTN1-to-partner and partner-to-ACTN1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, ACTN1 versus FN1 in OV, with a Pearson correlation of 0.64.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ACTN1→partner) and Y-score (partner→ACTN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	FN1 →	+2.233	+0.569	<.001	<.001	3	10
OV	CALD1 →	+1.348	+0.512	<.001	<.001	3	10
UCEC	CNN1 →	+2.686	+0.727	<.001	<.001	3	10
OV	TGFB1I1 →	+1.083	+0.517	<.001	<.001	3	10
OV	CDH11 →	+1.632	+0.575	<.001	<.001	3	10
GBM	COL6A2 →	+1.432	+0.433	.003	.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 18,381 associations by consensus.

ACTN1 vs FN1 — OV

Explore this scatter interactively →