ACTN1

Across TCGA patient cohorts, ACTN1 mutation is significantly associated with the RNA expression of many other genes, with 5,018 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ACTN1-associated genes across cancer lineages are TYW3, PBK, and ZWILCH. Each is linked with ACTN1 in more than 3 cancer types. Because this analysis shows association rather than direction, both ACTN1-to-partner and partner-to-ACTN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TYW3 grouped by ACTN1-low versus ACTN1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ACTN1→partner) and Y-score (partner→ACTN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TYW3 →	+0.357	+1.749	<.001	<.001	3	4
UCEC	PBK →	+0.839	+1.783	<.001	<.001	3	4
UCEC	ZWILCH →	+0.419	+2.289	<.001	<.001	3	4
STAD	SDHA →	+0.661	+3.203	.001	.009	3	4
UCEC	PRC1 →	+0.587	+2.233	<.001	<.001	3	4
UCEC	BNIP1 →	+0.313	+2.289	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,018 associations by consensus.

TYW3 by ACTN1 expression — UCEC

Explore this box plot interactively →