ACTL9

Across TCGA patient cohorts, ACTL9 RNA expression is significantly associated with the go_rna of many other GO terms, with 6,074 significant associations in total. STAD shows the largest number of these associations.

The most reproducible ACTL9-associated GO terms across cancer lineages are Activation of innate immune response, Tumor necrosis factor-mediated signaling pathway, and Regulation of protein serine/threonine kinase activity. Each is linked with ACTL9 in more than 9 cancer types. Because this analysis shows association rather than direction, both ACTL9-to-partner and partner-to-ACTL9 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Activation of innate immune response grouped by ACTL9-low versus ACTL9-high in STAD.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ACTL9→partner) and Y-score (partner→ACTL9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	Activation of innate immune response →	+0.047	+0.061	<.001	<.001	3	10
STAD	Tumor necrosis factor-mediated signaling pathway →	+0.049	+0.053	<.001	<.001	3	10
STAD	Regulation of protein serine/threonine kinase activity →	+0.049	+0.062	<.001	<.001	3	10
STAD	TOR signaling →	+0.055	+0.060	<.001	<.001	3	9
STAD	Negative regulation of protein binding →	+0.059	+0.062	<.001	<.001	3	9
STAD	Regulation of protein polymerization →	+0.051	+0.062	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,074 associations by consensus.

Activation of innate immune response by ACTL9 expression — STAD

Explore this box plot interactively →