ACTL9

Across TCGA patient cohorts, ACTL9 mutation is significantly associated with the RNA expression of many other genes, with 2,819 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ACTL9-associated genes across cancer lineages are KIF23, BUB3, and SKA1. Each is linked with ACTL9 in more than 3 cancer types. Because this analysis shows association rather than direction, both ACTL9-to-partner and partner-to-ACTL9 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KIF23 grouped by ACTL9-low versus ACTL9-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ACTL9→partner) and Y-score (partner→ACTL9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	KIF23 →	+0.566	+2.721	.004	.003	3	4
UCEC	BUB3 →	+0.462	+3.162	<.001	<.001	3	3
UCEC	SKA1 →	+0.705	+3.024	<.001	<.001	3	3
UCEC	CDC25A →	+0.584	+1.736	.002	.007	3	3
UCEC	DDIAS →	+0.617	+2.815	<.001	.001	3	3
UCEC	CENPN →	+0.626	+2.480	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,819 associations by consensus.

KIF23 by ACTL9 expression — UCEC

Explore this box plot interactively →