ACTL9

Across TCGA patient cohorts, ACTL9 mutation is significantly associated with the total protein of many other genes, with 31 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ACTL9-associated genes across cancer lineages are A-Raf_pS299, FoxM1, and p90 RSK. Each is linked with ACTL9 in more than 2 cancer types. Because this analysis shows association rather than direction, both ACTL9-to-partner and partner-to-ACTL9 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, A-Raf_pS299 grouped by ACTL9-low versus ACTL9-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ACTL9→partner) and Y-score (partner→ACTL9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	A-Raf_pS299 →	-0.122	-3.169	.019	.019	3	2
COAD	FoxM1 →	+0.607	+3.330	<.001	.005	3	2
COAD	p90 RSK →	+0.301	+2.178	.015	.035	3	2
COAD	ASNS →	+0.578	+3.330	.001	.005	3	2
LUSC	PEA-15_pS116 →	+0.347	+3.009	.011	.019	2	2
UCEC	eIF4E →	+0.190	+3.169	.039	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 31 associations by consensus.

A-Raf_pS299 by ACTL9 expression — UCEC

Explore this box plot interactively →