ACTL9

Across TCGA cell cohorts, ACTL9 mutation is significantly associated with the RNA expression of many other genes, with 14 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible ACTL9-associated genes across cancer lineages are DEFB125, USP29, and PROP1. Each is linked with ACTL9 in more than 1 cancer types. Because this analysis shows association rather than direction, both ACTL9-to-partner and partner-to-ACTL9 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DEFB125 grouped by ACTL9-low versus ACTL9-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ACTL9→partner) and Y-score (partner→ACTL9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	DEFB125 →	+0.086	+5.643	<.001	.002	3	1
LUNG_NSCLC_LUAD	USP29 →	+0.012	+4.662	<.001	.005	3	1
LUNG_NSCLC_LUAD	PROP1 →	+0.028	+4.734	<.001	.002	3	1
LUNG_NSCLC_LUAD	OOSP4B →	+0.017	+5.266	<.001	.001	3	1
SKIN	HSFY2 →	+0.016	+3.345	<.001	.007	3	1
SKIN	HSFY1 →	+0.006	+4.022	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

DEFB125 by ACTL9 expression — LUNG_SCLC

Explore this box plot interactively →