ACTL8

Across TCGA patient cohorts, ACTL8 RNA expression is significantly associated with the go_rna of many other GO terms, with 6,769 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible ACTL8-associated GO terms across cancer lineages are DNA replication initiation, tRNA 5'-leader removal, and scaRNA localization to Cajal body. Each is linked with ACTL8 in more than 16 cancer types. Because this analysis shows association rather than direction, both ACTL8-to-partner and partner-to-ACTL8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DNA replication initiation grouped by ACTL8-low versus ACTL8-high in STAD.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ACTL8→partner) and Y-score (partner→ACTL8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	DNA replication initiation →	+0.062	+0.998	<.001	<.001	3	17
TGCT	tRNA 5'-leader removal →	+0.050	+0.770	<.001	<.001	3	16
STAD	scaRNA localization to Cajal body →	+0.060	+0.803	<.001	<.001	3	15
STAD	Positive regulation of mitotic cytokinesis →	+0.105	+0.825	<.001	<.001	2	16
STAD	Positive regulation of telomerase RNA localization to Cajal body →	+0.067	+0.718	<.001	.001	2	16
STAD	G2/MI transition of meiotic cell cycle →	+0.081	+0.688	<.001	<.001	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,769 associations by consensus.

DNA replication initiation by ACTL8 expression — STAD

Explore this box plot interactively →