ACTL8

Across TCGA patient cohorts, ACTL8 mutation is significantly associated with the total protein of many other genes, with 23 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ACTL8-associated genes across cancer lineages are Cyclin-B1, eIF4E, and Caspase-7-cleavedD198. Each is linked with ACTL8 in more than 2 cancer types. Because this analysis shows association rather than direction, both ACTL8-to-partner and partner-to-ACTL8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-B1 grouped by ACTL8-low versus ACTL8-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ACTL8→partner) and Y-score (partner→ACTL8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	Cyclin-B1 →	+0.442	+2.807	.012	.003	3	3
UCEC	eIF4E →	+0.158	+2.820	.046	.035	3	2
UCEC	Caspase-7-cleavedD198 →	+0.693	+3.604	.001	.001	3	2
UCEC	CD20 →	+0.109	+1.605	.027	.041	3	2
SKCM	INPP4B →	-0.177	-2.098	.034	.018	3	2
SKCM	Rab25 →	-0.216	-2.974	.049	.035	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

Cyclin-B1 by ACTL8 expression — SKCM

Explore this box plot interactively →