ACTL8

Across TCGA cell cohorts, ACTL8 RNA expression is significantly associated with the go_rna of many other GO terms, with 1,660 significant associations in total. BONE shows the largest number of these associations.

The most reproducible ACTL8-associated GO terms across cancer lineages are Poly(A)-dependent snoRNA 3'-end processing, scaRNA localization to Cajal body, and Regulation of ERK1 and ERK2 cascade. Each is linked with ACTL8 in more than 7 cancer types. Because this analysis shows association rather than direction, both ACTL8-to-partner and partner-to-ACTL8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Poly(A)-dependent snoRNA 3'-end processing grouped by ACTL8-low versus ACTL8-high in BLOOD_Myeloma.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ACTL8→partner) and Y-score (partner→ACTL8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	Poly(A)-dependent snoRNA 3'-end processing →	+0.123	+4.056	.001	.001	3	7
BONE	scaRNA localization to Cajal body →	+0.101	+0.838	.001	.007	2	8
SKIN	Regulation of ERK1 and ERK2 cascade →	-0.028	-1.046	.002	.002	2	8
CNS	tRNA aminoacylation for mitochondrial protein translation →	+0.082	+0.470	<.001	.001	3	6
BONE	tRNA processing →	+0.061	+0.678	.001	.008	3	6
BONE	Mitochondrial RNA metabolic process →	+0.107	+1.114	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,660 associations by consensus.

Poly(A)-dependent snoRNA 3'-end processing by ACTL8 expression — BLOOD_Myeloma

Explore this box plot interactively →