ACTL8

Across TCGA cell cohorts, ACTL8 mutation is significantly associated with the RNA expression of many other genes, with 30 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ACTL8-associated genes across cancer lineages are TNP1, DPT, and LRIT1. Each is linked with ACTL8 in more than 1 cancer types. Because this analysis shows association rather than direction, both ACTL8-to-partner and partner-to-ACTL8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TNP1 grouped by ACTL8-low versus ACTL8-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ACTL8→partner) and Y-score (partner→ACTL8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	TNP1 →	+0.111	+4.569	<.001	.003	3	1
BLOOD_Leukemia	DPT →	+1.247	+4.091	<.001	.002	3	1
BLOOD_Leukemia	LRIT1 →	+0.030	+3.684	<.001	.004	3	1
BLOOD_Leukemia	RGR →	+0.029	+3.684	<.001	.004	3	1
BLOOD_Leukemia	SCGB3A2 →	+0.099	+3.922	<.001	.002	3	1
BLOOD_Leukemia	OR13J1 →	+0.159	+4.096	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 30 associations by consensus.

TNP1 by ACTL8 expression — BLOOD_Leukemia

Explore this box plot interactively →