ACTL6B

Across TCGA patient cohorts, ACTL6B mutation is significantly associated with the total protein of many other genes, with 32 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ACTL6B-associated genes across cancer lineages are EGFR_pY1068, EGFR, and A-Raf_pS299. Each is linked with ACTL6B in more than 1 cancer types. Because this analysis shows association rather than direction, both ACTL6B-to-partner and partner-to-ACTL6B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by ACTL6B-low versus ACTL6B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ACTL6B→partner) and Y-score (partner→ACTL6B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.217	-2.000	.028	.010	3	1
UCEC	EGFR →	-0.133	-3.169	.034	.019	3	1
UCEC	A-Raf_pS299 →	-0.130	-3.169	.005	.019	3	1
UCEC	ERK2 →	+0.177	+1.807	.019	.025	3	1
UCEC	HER3 →	-0.234	-3.159	.030	.019	3	1
UCEC	INPP4B →	-0.289	-3.321	.023	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 32 associations by consensus.

EGFR_pY1068 by ACTL6B expression — UCEC

Explore this box plot interactively →