ACTL6B

Across TCGA cell cohorts, ACTL6B RNA expression is significantly associated with the go_rna of many other GO terms, with 1,622 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible ACTL6B-associated GO terms across cancer lineages are Regulation of myoblast fusion, Negative regulation of syncytium formation by plasma membrane fusion, and Regulation of calcium ion transport into cytosol. Each is linked with ACTL6B in more than 6 cancer types. Because this analysis shows association rather than direction, both ACTL6B-to-partner and partner-to-ACTL6B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of myoblast fusion grouped by ACTL6B-low versus ACTL6B-high in BLOOD_Leukemia.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ACTL6B→partner) and Y-score (partner→ACTL6B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	Regulation of myoblast fusion →	+0.039	+0.066	.005	.008	3	7
LUNG_SCLC	Negative regulation of syncytium formation by plasma membrane fusion →	+0.064	+2.263	.008	<.001	3	6
SOFT_TISSUE	Regulation of calcium ion transport into cytosol →	-0.213	-0.122	<.001	.002	3	5
LUNG_SCLC	Regulation of stem cell population maintenance →	+0.098	+2.754	<.001	<.001	3	5
SOFT_TISSUE	Purine nucleoside triphosphate biosynthetic process →	+0.054	+0.121	.009	.007	3	5
SOFT_TISSUE	Purine ribonucleoside triphosphate biosynthetic process →	+0.054	+0.121	.009	.007	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,622 associations by consensus.

Regulation of myoblast fusion by ACTL6B expression — BLOOD_Leukemia

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