ACTL6B

Across TCGA cell cohorts, ACTL6B mutation is significantly associated with the RNA expression of many other genes, with 31 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ACTL6B-associated genes across cancer lineages are RIT2, TPRX1, and LY6G6D. Each is linked with ACTL6B in more than 1 cancer types. Because this analysis shows association rather than direction, both ACTL6B-to-partner and partner-to-ACTL6B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RIT2 grouped by ACTL6B-low versus ACTL6B-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ACTL6B→partner) and Y-score (partner→ACTL6B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	RIT2 →	+0.030	+5.022	<.001	.002	3	1
SKIN	TPRX1 →	+0.017	+4.273	<.001	.006	3	1
SKIN	LY6G6D →	+0.106	+4.273	<.001	.006	3	1
CNS	ACSM2B →	+0.013	+5.321	<.001	.005	3	1
BLOOD_Leukemia	SLC32A1 →	+0.814	+4.223	<.001	.001	3	1
BLOOD_Leukemia	GML →	+0.073	+3.567	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 31 associations by consensus.

RIT2 by ACTL6B expression — SKIN

Explore this box plot interactively →