ACTG1P25

Across TCGA patient cohorts, ACTG1P25 mutation is significantly associated with the RNA expression of many other genes, with 311 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ACTG1P25-associated genes across cancer lineages are OR5AN1, MT-TS1, and RNU6-821P. Each is linked with ACTG1P25 in more than 1 cancer types. Because this analysis shows association rather than direction, both ACTG1P25-to-partner and partner-to-ACTG1P25 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR5AN1 grouped by ACTG1P25-low versus ACTG1P25-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ACTG1P25→partner) and Y-score (partner→ACTG1P25) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	OR5AN1 →	+0.081	+6.444	<.001	.001	3	1
BLCA	MT-TS1 →	+0.372	+6.618	<.001	.001	3	1
BLCA	RNU6-821P →	+0.335	+5.497	<.001	.004	3	1
UCEC	CCDC89 →	-0.939	-3.459	.002	.005	3	1
UCEC	ZSCAN22 →	+0.427	+3.459	.005	.005	3	1
UCEC	PRORY →	+0.032	+4.148	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 311 associations by consensus.

OR5AN1 by ACTG1P25 expression — BLCA

Explore this box plot interactively →