Across TCGA pan-cancer cohorts, ACTG1P11 RNA differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of ACTG1P11’s most consistent transcriptional readouts.
The strongest signal is observed in breast invasive carcinoma (BRCA), where ACTG1P11 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types ACTG1P11 is over-expressed in tumor, although a few such as COAD show the opposite, repressed pattern.
BRCA, COAD, and LUAD are the cancer types where ACTG1P11 tumor–normal differential expression is most reproducible.