ACTC1

Across TCGA pan-cancer cohorts, ACTC1 mass-spec protein is linked to patient survival in 2 of 34 cancer types, making it a survival-associated ACTC1 data layer compared with 29 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in glioblastoma multiforme (GBM), where higher ACTC1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated ACTC1 expression acts as an unfavorable survival marker.

GBM and HNSC are the cancer types where ACTC1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
GBM	DFS	Quartile	All	0.206	0.833	.006	14	view →
HNSC	DFS	Quartile	II,III,IV	0.351	1.000	.014	2	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

ACTC1–GBM (DFS)

Open the GBM breakdown →