ACTC1

Across TCGA patient cohorts, ACTC1 protein abundance is significantly associated with the RNA expression of many other genes, with 516 significant associations in total. GBM shows the largest number of these associations.

The most reproducible ACTC1-associated genes across cancer lineages are PABPC1L, SALL4, and DIDO1. Each is linked with ACTC1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ACTC1-to-partner and partner-to-ACTC1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, ACTC1 versus PABPC1L in GBM, with a Pearson correlation of -0.58.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ACTC1→partner) and Y-score (partner→ACTC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	PABPC1L →	-1.144	-0.507	.001	<.001	3	1
GBM	SALL4 →	-1.647	-0.443	<.001	.003	3	1
GBM	DIDO1 →	-0.800	-0.526	.001	.006	3	1
GBM	PAK5 →	+0.987	+0.425	.005	.005	3	1
GBM	RUBCNL →	-0.984	-0.485	.007	<.001	3	1
GBM	TAF1C →	-0.836	-0.555	.004	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 516 associations by consensus.

ACTC1 vs PABPC1L — GBM

Explore this scatter interactively →