ACTC1

Across TCGA patient cohorts, ACTC1 mutation is significantly associated with the RNA expression of many other genes, with 2,320 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ACTC1-associated genes across cancer lineages are SRSF4, TUBGCP5, and WHAMM. Each is linked with ACTC1 in more than 3 cancer types. Because this analysis shows association rather than direction, both ACTC1-to-partner and partner-to-ACTC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SRSF4 grouped by ACTC1-low versus ACTC1-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ACTC1→partner) and Y-score (partner→ACTC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	SRSF4 →	+0.385	+3.357	.003	.005	3	4
UCEC	TUBGCP5 →	+0.417	+2.769	.002	<.001	3	3
UCEC	WHAMM →	+0.557	+3.839	<.001	<.001	3	3
UCEC	DFFA →	+0.573	+3.010	<.001	<.001	3	3
UCEC	RBM15 →	+0.471	+2.732	<.001	.003	3	3
UCEC	ATAD3A →	+0.511	+3.732	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,320 associations by consensus.

SRSF4 by ACTC1 expression — LUSC

Explore this box plot interactively →