ACTC1

Across TCGA patient cohorts, ACTC1 mutation is significantly associated with the total protein of many other genes, with 25 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ACTC1-associated genes across cancer lineages are MSH6, Caspase-8, and XRCC1. Each is linked with ACTC1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ACTC1-to-partner and partner-to-ACTC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MSH6 grouped by ACTC1-low versus ACTC1-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ACTC1→partner) and Y-score (partner→ACTC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	MSH6 →	+0.396	+2.179	.039	.035	3	2
UCEC	Caspase-8 →	-0.249	-2.558	.011	.010	3	2
LUSC	XRCC1 →	+0.164	+2.179	.032	.035	3	1
SKCM	eIF4G →	+0.339	+2.115	.048	.018	3	1
SKCM	NDRG1_pT346 →	-0.607	-2.115	.034	.018	3	1
SKCM	p90 RSK →	+0.214	+2.115	.019	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

MSH6 by ACTC1 expression — LUSC

Explore this box plot interactively →