ACTC1

Across TCGA cell cohorts, ACTC1 mutation is significantly associated with the RNA expression of many other genes, with 310 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ACTC1-associated genes across cancer lineages are KDELR1, SH3GL2, and C1QBP. Each is linked with ACTC1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ACTC1-to-partner and partner-to-ACTC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KDELR1 grouped by ACTC1-low versus ACTC1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ACTC1→partner) and Y-score (partner→ACTC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	KDELR1 →	+0.532	+3.087	.005	.006	3	1
LARGE_INTESTINE	SH3GL2 →	+1.368	+3.667	<.001	<.001	3	1
LARGE_INTESTINE	C1QBP →	+0.790	+3.299	<.001	.004	3	1
LARGE_INTESTINE	MRPL2 →	+0.468	+3.212	.004	.006	3	1
LARGE_INTESTINE	WRAP73 →	+0.601	+3.212	.002	.006	3	1
LARGE_INTESTINE	ATP5PB →	+0.515	+3.212	.002	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 310 associations by consensus.

KDELR1 by ACTC1 expression — LARGE_INTESTINE

Explore this box plot interactively →