ACTBL2

Across TCGA patient cohorts, ACTBL2 mutation is significantly associated with the RNA expression of many other genes, with 2,305 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ACTBL2-associated genes across cancer lineages are RPS29P32, ADM, and ADAM33. Each is linked with ACTBL2 in more than 2 cancer types. Because this analysis shows association rather than direction, both ACTBL2-to-partner and partner-to-ACTBL2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RPS29P32 grouped by ACTBL2-low versus ACTBL2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ACTBL2→partner) and Y-score (partner→ACTBL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RPS29P32 →	+0.416	+2.319	<.001	.001	3	3
UCEC	ADM →	+1.195	+2.332	<.001	<.001	3	2
UCEC	ADAM33 →	-0.805	-1.915	.005	.005	3	2
UCEC	FCGR1A →	+0.669	+3.742	<.001	<.001	3	2
COAD	OXSM →	+0.482	+3.392	<.001	.004	3	2
UCEC	SLC25A4 →	+0.532	+2.233	<.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,305 associations by consensus.

RPS29P32 by ACTBL2 expression — UCEC

Explore this box plot interactively →