ACTBL2

Across TCGA patient cohorts, ACTBL2 mutation is significantly associated with the total protein of many other genes, with 33 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ACTBL2-associated genes across cancer lineages are MEK1, Notch1, and Rictor_pT1135. Each is linked with ACTBL2 in more than 2 cancer types. Because this analysis shows association rather than direction, both ACTBL2-to-partner and partner-to-ACTBL2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by ACTBL2-low versus ACTBL2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ACTBL2→partner) and Y-score (partner→ACTBL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.554	+3.247	<.001	<.001	3	3
UCEC	Notch1 →	+0.202	+2.598	<.001	.005	3	2
UCEC	Rictor_pT1135 →	-0.102	-2.584	.009	.010	3	2
UCEC	TFRC →	+0.512	+2.321	.011	.033	3	2
UCEC	TIGAR →	+0.125	+2.459	.032	.019	3	2
UCEC	VEGFR2 →	+0.257	+3.169	.024	.018	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 33 associations by consensus.

MEK1 by ACTBL2 expression — UCEC

Explore this box plot interactively →