ACTB

Across TCGA patient cohorts, ACTB mutation is significantly associated with the total protein of many other genes, with 14 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ACTB-associated genes across cancer lineages are Notch1, PCNA, and PDCD4. Each is linked with ACTB in more than 1 cancer types. Because this analysis shows association rather than direction, both ACTB-to-partner and partner-to-ACTB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by ACTB-low versus ACTB-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ACTB→partner) and Y-score (partner→ACTB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.158	+1.765	.002	.014	3	2
UCEC	PCNA →	+0.199	+1.765	.014	.014	3	2
UCEC	PDCD4 →	-0.622	-2.312	<.001	.005	3	2
UCEC	Src →	+0.155	+1.900	.045	.028	3	2
UCEC	eIF4E →	+0.180	+3.183	.022	.009	3	1
UCEC	p27 →	+0.185	+1.807	.024	.025	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

Notch1 by ACTB expression — UCEC

Explore this box plot interactively →