ACTB

Across TCGA cell cohorts, ACTB RNA expression is significantly associated with the go_rna of many other GO terms, with 5,155 significant associations in total. BONE shows the largest number of these associations.

The most reproducible ACTB-associated GO terms across cancer lineages are Actin filament organization, Positive regulation of stress fiber assembly, and Integrin-mediated signaling pathway. Each is linked with ACTB in more than 14 cancer types. Because this analysis shows association rather than direction, both ACTB-to-partner and partner-to-ACTB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Actin filament organization grouped by ACTB-low versus ACTB-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ACTB→partner) and Y-score (partner→ACTB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Actin filament organization →	+0.131	+0.858	<.001	<.001	3	15
BONE	Positive regulation of stress fiber assembly →	+0.179	+0.854	<.001	<.001	3	15
BONE	Integrin-mediated signaling pathway →	+0.254	+0.718	<.001	<.001	3	14
BONE	Positive regulation of actin filament bundle assembly →	+0.188	+0.799	<.001	<.001	3	14
BONE	Positive regulation of cell-substrate adhesion →	+0.140	+0.789	<.001	<.001	3	14
BONE	Blood vessel morphogenesis →	+0.095	+0.960	<.001	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,155 associations by consensus.

Actin filament organization by ACTB expression — BONE

Explore this box plot interactively →