ACTB

Across TCGA cell cohorts, ACTB mutation is significantly associated with the RNA expression of many other genes, with 21 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ACTB-associated genes across cancer lineages are KRT71, PRSS54, and LGI1. Each is linked with ACTB in more than 1 cancer types. Because this analysis shows association rather than direction, both ACTB-to-partner and partner-to-ACTB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KRT71 grouped by ACTB-low versus ACTB-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ACTB→partner) and Y-score (partner→ACTB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	KRT71 →	+0.007	+4.058	<.001	.009	3	1
URINARY_TRACT	PRSS54 →	+0.011	+3.459	<.001	.002	3	1
BLOOD_Leukemia	LGI1 →	+0.056	+4.124	<.001	<.001	3	1
BLOOD_Leukemia	GSC →	+0.701	+2.948	.008	.008	3	1
BLOOD_Leukemia	LRRC38 →	+1.473	+3.894	<.001	.001	3	1
BLOOD_Leukemia	FAM110C →	+0.969	+3.554	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

KRT71 by ACTB expression — BLOOD_Lymphoma

Explore this box plot interactively →