ACTA2

Across TCGA patient cohorts, ACTA2 protein abundance is significantly associated with the RNA expression of many other genes, with 11,456 significant associations in total. GBM shows the largest number of these associations.

The most reproducible ACTA2-associated genes across cancer lineages are MYL9, CNN1, and TAGLN. Each is linked with ACTA2 in more than 7 cancer types. Because this analysis shows association rather than direction, both ACTA2-to-partner and partner-to-ACTA2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, ACTA2 versus MYL9 in UCEC, with a Pearson correlation of 0.39.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ACTA2→partner) and Y-score (partner→ACTA2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MYL9 →	+1.434	+1.030	<.001	<.001	3	8
UCEC	CNN1 →	+2.147	+0.816	<.001	<.001	3	8
UCEC	TAGLN →	+1.466	+0.849	.001	<.001	3	8
UCEC	MYLK →	+1.071	+0.879	<.001	<.001	3	8
BRCA	DPYSL3 →	+1.253	+0.939	<.001	<.001	3	7
BRCA	AOC3 →	+1.159	+0.795	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,456 associations by consensus.

ACTA2 vs MYL9 — UCEC

Explore this scatter interactively →