ACTA2

Across TCGA patient cohorts, ACTA2 mutation is significantly associated with the total protein of many other genes, with 26 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ACTA2-associated genes across cancer lineages are Notch1, PDCD4, and Tuberin_pT1462. Each is linked with ACTA2 in more than 1 cancer types. Because this analysis shows association rather than direction, both ACTA2-to-partner and partner-to-ACTA2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by ACTA2-low versus ACTA2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ACTA2→partner) and Y-score (partner→ACTA2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.228	+2.820	<.001	.001	3	2
UCEC	PDCD4 →	-0.521	-3.459	.002	.005	3	2
UCEC	Tuberin_pT1462 →	+0.188	+1.817	.026	.015	3	2
UCEC	EGFR →	-0.139	-1.847	.017	.008	3	1
UCEC	eIF4E →	+0.185	+2.247	.017	.001	3	1
UCEC	FASN →	+0.336	+2.459	.020	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 26 associations by consensus.

Notch1 by ACTA2 expression — UCEC

Explore this box plot interactively →