ACTA2

Across TCGA cell cohorts, ACTA2 mutation is significantly associated with the mutation status of many other genes, with 1,085 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ACTA2-associated genes across cancer lineages are SYNC, C19orf54, and TXN2. Each is linked with ACTA2 in more than 2 cancer types. Because this analysis shows association rather than direction, both ACTA2-to-partner and partner-to-ACTA2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SYNC grouped by ACTA2-low versus ACTA2-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ACTA2→partner) and Y-score (partner→ACTA2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	SYNC →	+5.894	+5.321	.002	.002	1	3
BLOOD_Leukemia	C19orf54 →	+4.309	+4.560	.007	.007	1	3
BLOOD_Leukemia	TXN2 →	+5.479	+6.145	<.001	<.001	1	2
BLOOD_Leukemia	FOXRED2 →	+3.479	+4.932	.002	.002	1	2
BLOOD_Leukemia	DCAF11 →	+5.894	+5.321	.002	.002	1	2
BLOOD_Leukemia	CLCN7 →	+4.894	+4.894	.004	.004	1	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,085 associations by consensus.

SYNC by ACTA2 expression — BLOOD_Leukemia

Explore this box plot interactively →