ACTA1

Across TCGA pan-cancer cohorts, ACTA1 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated ACTA1 data layer compared with 28 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher ACTA1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated ACTA1 expression acts as an unfavorable survival marker, although some lineages such as HNSC show a favorable association.

LSCC, UCEC, and LUAD are the cancer types where ACTA1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Quartile	All	0.858	1.000	.006	35	view →
UCEC	DFS	Tertile	III,IV	0.376	1.000	.013	20	view →
LUAD	DFS	Quartile	All	0.818	0.979	.008	15	view →
PDAC	OS	Quartile	All	0.838	0.982	.021	3	view →
CCRCC	OS	Median	III,IV	0.103	0.985	.044	3	view →
HNSC	DFS	Median	III,IV	1.000	0.939	.043	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

ACTA1–LSCC (DFS)

Open the LSCC breakdown →