ACTA1

Across TCGA patient cohorts, ACTA1 protein abundance is significantly associated with the RNA expression of many other genes, with 6,667 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible ACTA1-associated genes across cancer lineages are DES, MYL9, and CNN1. Each is linked with ACTA1 in more than 6 cancer types. Because this analysis shows association rather than direction, both ACTA1-to-partner and partner-to-ACTA1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, ACTA1 versus DES in HNSC, with a Pearson correlation of 0.70.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ACTA1→partner) and Y-score (partner→ACTA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	DES →	+3.428	+1.010	<.001	<.001	3	7
CCRCC	MYL9 →	+1.226	+0.667	<.001	<.001	3	6
UCEC	CNN1 →	+2.308	+0.693	<.001	<.001	3	6
CCRCC	AOC3 →	+0.979	+0.629	<.001	<.001	3	6
HNSC	LYVE1 →	+1.377	+1.198	<.001	<.001	3	6
HNSC	PDLIM3 →	+1.424	+1.187	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,667 associations by consensus.

ACTA1 vs DES — HNSC

Explore this scatter interactively →