ACTA1

Across TCGA patient cohorts, ACTA1 mutation is significantly associated with the RNA expression of many other genes, with 2,063 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ACTA1-associated genes across cancer lineages are LRRC6P1, SKA1, and MED28P2. Each is linked with ACTA1 in more than 2 cancer types. Because this analysis shows association rather than direction, both ACTA1-to-partner and partner-to-ACTA1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LRRC6P1 grouped by ACTA1-low versus ACTA1-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ACTA1→partner) and Y-score (partner→ACTA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	LRRC6P1 →	+0.034	+8.055	<.001	.007	3	3
UCEC	SKA1 →	+0.599	+3.606	.001	.001	3	3
SKCM	MED28P2 →	+0.049	+4.634	<.001	.003	3	3
COAD	VPS18 →	+0.532	+3.700	.001	.001	3	3
UCEC	CCL5 →	+0.810	+2.606	.007	<.001	3	2
UCEC	CCL4 →	+0.728	+2.606	.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,063 associations by consensus.

LRRC6P1 by ACTA1 expression — BRCA

Explore this box plot interactively →