ACTA1

Across TCGA patient cohorts, ACTA1 mutation is significantly associated with the total protein of many other genes, with 45 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ACTA1-associated genes across cancer lineages are EGFR_pY1068, Caspase-7-cleavedD198, and mTOR_pS2448. Each is linked with ACTA1 in more than 2 cancer types. Because this analysis shows association rather than direction, both ACTA1-to-partner and partner-to-ACTA1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by ACTA1-low versus ACTA1-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ACTA1→partner) and Y-score (partner→ACTA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	EGFR_pY1068 →	-0.427	-3.000	.003	.034	3	3
COAD	Caspase-7-cleavedD198 →	+1.370	+2.330	<.001	.020	3	3
COAD	mTOR_pS2448 →	-0.254	-2.313	.001	.035	2	3
UCEC	Notch1 →	+0.157	+2.598	.001	.005	3	2
UCEC	PKC-b-II_pS660 →	-0.212	-1.807	.033	.025	3	2
COAD	Rad50 →	-0.353	-3.296	.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 45 associations by consensus.

EGFR_pY1068 by ACTA1 expression — COAD

Explore this box plot interactively →