ACTA1

Across TCGA cell cohorts, ACTA1 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,411 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible ACTA1-associated GO terms across cancer lineages are Spliceosomal complex assembly, Negative regulation of mRNA metabolic process, and Epigenetic regulation of gene expression. Each is linked with ACTA1 in more than 8 cancer types. Because this analysis shows association rather than direction, both ACTA1-to-partner and partner-to-ACTA1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Spliceosomal complex assembly grouped by ACTA1-low versus ACTA1-high in SOFT_TISSUE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ACTA1→partner) and Y-score (partner→ACTA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	Spliceosomal complex assembly →	+0.081	+1.538	.001	.005	3	9
SOFT_TISSUE	Negative regulation of mRNA metabolic process →	+0.045	+0.922	.001	.002	3	9
LUNG_SCLC	Epigenetic regulation of gene expression →	+0.067	+0.430	<.001	<.001	3	8
SOFT_TISSUE	Regulation of transcription by RNA polymerase I →	+0.082	+1.195	<.001	.005	3	8
SOFT_TISSUE	Chromosomal 5-methylcytosine DNA demethylation pathway →	+0.127	+1.343	<.001	.005	3	8
LARGE_INTESTINE	Positive regulation of double-strand break repair via homologous recombination →	+0.064	+0.192	<.001	.003	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,411 associations by consensus.

Spliceosomal complex assembly by ACTA1 expression — SOFT_TISSUE

Explore this box plot interactively →