ACSS3

Across TCGA patient cohorts, ACSS3 protein abundance is significantly associated with the protein abundance of many other proteins, with 22,994 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible ACSS3-associated proteins across cancer lineages are SMC2, CDC20_T70, and XRCC6_T455. Each is linked with ACSS3 in more than 5 cancer types. Because this analysis shows association rather than direction, both ACSS3-to-partner and partner-to-ACSS3 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, ACSS3 versus SMC2 in LSCC, with a Pearson correlation of -0.53.

protein abundance associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (ACSS3→partner) and Y-score (partner→ACSS3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	SMC2 →	-0.535	-0.341	<.001	<.001	3	6
PDAC	CDC20_T70 →	-0.925	-0.271	<.001	<.001	3	6
LSCC	XRCC6_T455 →	-0.739	-0.511	<.001	.001	3	6
BRCA	AKAP12_S1331 →	+0.759	+0.585	<.001	<.001	3	6
HNSC	MAMDC2 →	+0.885	+0.527	<.001	<.001	3	6
GBM	SLC27A1 →	+0.342	+0.547	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 22,994 associations by consensus.

ACSS3 vs SMC2 — LSCC

Explore this scatter interactively →