ACSS3

Across TCGA patient cohorts, ACSS3 mutation is significantly associated with the total protein of many other genes, with 50 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible ACSS3-associated genes across cancer lineages are cIAP, Ku80, and Bid. Each is linked with ACSS3 in more than 2 cancer types. Because this analysis shows association rather than direction, both ACSS3-to-partner and partner-to-ACSS3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, cIAP grouped by ACSS3-low versus ACSS3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ACSS3→partner) and Y-score (partner→ACSS3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	cIAP →	+0.130	+1.933	.018	.009	3	3
UCEC	Ku80 →	+0.229	+1.498	.015	.036	3	3
SKCM	Bid →	-0.125	-1.807	.036	.024	3	2
UCEC	JNK_pT183_Y185 →	-0.168	-1.893	.013	.016	3	2
SKCM	Lck →	-0.241	-1.700	.041	.040	3	2
SKCM	VHL →	-0.496	-2.459	.040	.017	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 50 associations by consensus.

cIAP by ACSS3 expression — UCEC

Explore this box plot interactively →