ACSS3

Across TCGA cell cohorts, ACSS3 mutation is significantly associated with the RNA expression of many other genes, with 75 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ACSS3-associated genes across cancer lineages are HTR3D, IFNA1, and TMEM196. Each is linked with ACSS3 in more than 1 cancer types. Because this analysis shows association rather than direction, both ACSS3-to-partner and partner-to-ACSS3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HTR3D grouped by ACSS3-low versus ACSS3-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ACSS3→partner) and Y-score (partner→ACSS3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	HTR3D →	+0.008	+3.925	<.001	.006	3	2
BLOOD_Myeloma	IFNA1 →	+0.030	+4.807	<.001	.006	3	1
OESOPHAGUS	TMEM196 →	+0.069	+4.017	<.001	.007	3	1
LARGE_INTESTINE	CHIA →	+0.025	+2.538	.001	.005	3	1
LARGE_INTESTINE	PLCD3 →	-1.237	-3.278	<.001	.006	3	1
LARGE_INTESTINE	NUDT13 →	-0.517	-3.278	.008	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 75 associations by consensus.

HTR3D by ACSS3 expression — BLOOD_Lymphoma

Explore this box plot interactively →