ACSS2

Across TCGA patient cohorts, ACSS2 mutation is significantly associated with the RNA expression of many other genes, with 2,476 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ACSS2-associated genes across cancer lineages are DDX55, IGHD3-22, and IGHD3-16. Each is linked with ACSS2 in more than 1 cancer types. Because this analysis shows association rather than direction, both ACSS2-to-partner and partner-to-ACSS2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DDX55 grouped by ACSS2-low versus ACSS2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ACSS2→partner) and Y-score (partner→ACSS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	DDX55 →	+0.377	+2.711	.002	.003	3	2
UCEC	IGHD3-22 →	+1.539	+1.854	<.001	<.001	3	2
UCEC	IGHD3-16 →	+1.339	+2.318	<.001	<.001	3	2
UCEC	FTH1P2 →	+0.781	+2.056	<.001	.005	3	2
UCEC	FTH1P4 →	+0.619	+3.638	<.001	<.001	3	2
UCEC	RNA5SP422 →	+0.659	+1.753	<.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,476 associations by consensus.

DDX55 by ACSS2 expression — UCEC

Explore this box plot interactively →