ACSS2

Across TCGA patient cohorts, ACSS2 mutation is significantly associated with the total protein of many other genes, with 45 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ACSS2-associated genes across cancer lineages are mTOR_pS2448, p27_pT198, and C-Raf. Each is linked with ACSS2 in more than 1 cancer types. Because this analysis shows association rather than direction, both ACSS2-to-partner and partner-to-ACSS2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, mTOR_pS2448 grouped by ACSS2-low versus ACSS2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ACSS2→partner) and Y-score (partner→ACSS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	mTOR_pS2448 →	-0.155	-2.886	.003	.001	3	2
UCEC	p27_pT198 →	+0.096	+1.925	.012	.005	3	2
UCEC	C-Raf →	+0.171	+1.807	<.001	.025	3	2
UCEC	14-3-3_beta →	-0.079	-2.432	.029	.018	3	1
UCEC	eEF2 →	+0.283	+2.321	.028	.033	3	1
UCEC	EGFR_pY1068 →	-0.280	-2.321	.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 45 associations by consensus.

mTOR_pS2448 by ACSS2 expression — UCEC

Explore this box plot interactively →