ACSS2

Across TCGA cell cohorts, ACSS2 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,608 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ACSS2-associated GO terms across cancer lineages are Acetate metabolic process, Acetyl-CoA metabolic process, and Acetyl-CoA biosynthetic process. Each is linked with ACSS2 in more than 16 cancer types. Because this analysis shows association rather than direction, both ACSS2-to-partner and partner-to-ACSS2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Acetate metabolic process grouped by ACSS2-low versus ACSS2-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ACSS2→partner) and Y-score (partner→ACSS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Acetate metabolic process →	+1.002	+1.013	<.001	<.001	3	17
OVARY	Acetyl-CoA metabolic process →	+0.136	+1.274	<.001	<.001	3	15
BREAST	Acetyl-CoA biosynthetic process →	+0.141	+1.054	<.001	<.001	3	13
BLOOD_Leukemia	Long-term memory →	+0.157	+1.373	<.001	<.001	3	12
LUNG_NSCLC_LUAD	Sterol metabolic process →	+0.083	+1.102	<.001	<.001	3	11
OESOPHAGUS	Short-chain fatty acid metabolic process →	+0.140	+1.179	.004	.003	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,608 associations by consensus.

Acetate metabolic process by ACSS2 expression — LUNG_SCLC

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