ACSM6

Across TCGA patient cohorts, ACSM6 mutation is significantly associated with the total protein of many other genes, with 30 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ACSM6-associated genes across cancer lineages are EGFR_pY1068, A-Raf_pS299, and GAPDH. Each is linked with ACSM6 in more than 1 cancer types. Because this analysis shows association rather than direction, both ACSM6-to-partner and partner-to-ACSM6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by ACSM6-low versus ACSM6-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ACSM6→partner) and Y-score (partner→ACSM6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.320	-2.584	.006	.011	3	1
UCEC	A-Raf_pS299 →	-0.192	-2.584	<.001	.011	3	1
UCEC	GAPDH →	+0.497	+2.999	.047	.035	3	1
UCEC	JNK2 →	+0.315	+2.584	<.001	.011	3	1
UCEC	Ku80 →	+0.284	+1.887	.009	.031	3	1
UCEC	MAPK_pT202_Y204 →	-0.588	-3.000	.007	.036	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 30 associations by consensus.

EGFR_pY1068 by ACSM6 expression — UCEC

Explore this box plot interactively →