ACSM3

Across TCGA patient cohorts, ACSM3 mutation is significantly associated with the total protein of many other genes, with 40 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ACSM3-associated genes across cancer lineages are JNK_pT183_Y185, eIF4E, and Caspase-7-cleavedD198. Each is linked with ACSM3 in more than 2 cancer types. Because this analysis shows association rather than direction, both ACSM3-to-partner and partner-to-ACSM3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK_pT183_Y185 grouped by ACSM3-low versus ACSM3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ACSM3→partner) and Y-score (partner→ACSM3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK_pT183_Y185 →	-0.145	-1.807	.006	.025	3	3
UCEC	eIF4E →	+0.200	+2.736	.002	<.001	3	2
UCEC	Caspase-7-cleavedD198 →	+0.599	+1.827	.001	.002	3	2
SKCM	Chk2_pT68 →	-0.165	-2.987	.034	.035	3	2
SKCM	Heregulin →	-0.169	-2.321	.049	.035	3	2
UCEC	14-3-3_beta →	-0.072	-1.880	.022	.014	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 40 associations by consensus.

JNK_pT183_Y185 by ACSM3 expression — UCEC

Explore this box plot interactively →