ACSM3

Across TCGA cell cohorts, ACSM3 mutation is significantly associated with the drug of many other genes, with 9 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ACSM3-associated genes across cancer lineages are Vismodegib, PI3Ka_4409, and GSK2256098C. Each is linked with ACSM3 in more than 1 cancer types. Because this analysis shows association rather than direction, both ACSM3-to-partner and partner-to-ACSM3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Vismodegib grouped by ACSM3-low versus ACSM3-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ACSM3→partner) and Y-score (partner→ACSM3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Vismodegib →	+0.395	+2.684	.007	.035	2	1
LARGE_INTESTINE	PI3Ka_4409 →	-0.440	-2.743	.013	.046	1	1
LARGE_INTESTINE	GSK2256098C →	+0.353	+3.129	.014	.014	1	1
LARGE_INTESTINE	GSK2110183B →	+0.673	+2.871	.019	.021	1	1
LARGE_INTESTINE	GSK626616AC →	+0.326	+3.000	.031	.017	1	1
LARGE_INTESTINE	Dacarbazine →	+0.380	+3.000	.003	.017	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

Vismodegib by ACSM3 expression — LARGE_INTESTINE

Explore this box plot interactively →