ACSM2B

Across TCGA pan-cancer cohorts, ACSM2B RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of ACSM2B’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where ACSM2B RNA is repressed in tumor relative to normal tissue. In most cancer types ACSM2B is over-expressed in tumor, although a few such as KICH and THCA show the opposite, repressed pattern.

KICH, THCA, and LUAD are the cancer types where ACSM2B tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ACSM2B RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Female	II,III,IV	−4.847	<.001	9	view →
THCA	Male	II,III,IV	−0.146	<.001	9	view →
LUAD	Female	II,III,IV	−0.058	<.001	8	view →
COAD	All	II,III,IV	−0.019	<.001	8	view →
KIRP	All	III,IV	−2.000	.004	6	view →
BRCA	All	All	−0.087	<.001	6	view →
CHOL	Male	All	−5.354	<.001	5	view →
UCEC	All	II,III,IV	−0.069	.012	4	view →
LIHC	Female	All	−1.552	.003	3	view →
READ	Male	All	−0.040	.005	3	view →
BLCA	Female	All	−0.020	<.001	3	view →
KIRC	All	II,III,IV	+0.977	.027	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

ACSM2B–KICH

Open the KICH breakdown →