Across TCGA patient cohorts, ACSM2A mutation is significantly associated with the RNA expression of many other genes, with 4,365 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ACSM2A-associated genes across cancer lineages are SMC3, RN7SL523P, and POLE2. Each is linked with ACSM2A in more than 2 cancer types. Because this analysis shows association rather than direction, both ACSM2A-to-partner and partner-to-ACSM2A results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ACSM2A→partner) and Y-score (partner→ACSM2A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	SMC3 →	+0.514	+3.596	.008	.001	3	3
LUAD	RN7SL523P →	+0.235	+2.774	<.001	.002	3	3
UCEC	POLE2 →	+0.578	+3.343	<.001	<.001	3	3
SKCM	PLEKHA1 →	+0.385	+1.951	<.001	.002	3	3
SKCM	RAF1 →	+0.257	+1.635	.004	.004	3	3
SKCM	ASNSD1 →	+0.341	+1.465	.009	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,365 associations by consensus.

Exploration

ACSM2A survival (RNA) · tumor vs normal (RNA) · all ACSM2A data types